Postdoctoral cryo-EM position for the study of redox- relay signaling complexes

Brussels VIB-VUB Center for Structural Biology

06 Apr 2021

Brussels

VIB-VUB Center for Structural Biology

Joris Messens Lab

Post-doctoral

1

Position

A postdoctoral research position is immediately available for structure-function studies of proteins involved in redox signaling. Successful candidates will join the exciting research environment of the Messens VIB-laboratory at the Center for Structural Biology, Brussels, Belgium and home of the facility for Bio Electron Cryogenic Microscopy (https://becm.be). The Messens laboratory is recognized as a world leader in the redox field, and the lab provides an outstanding position in protein biochemistry and structural biology, in a highly dynamic and team-oriented research group. In this cutting-edge research environment, you will tackle essential biological problems in redox signaling using your structural biology cryo-EM expertise.

Mission of the lab

Redox and metabolite signaling are crucial for the proper functioning of the cell. But what are the exact players involved? And by which mechanisms does signaling proceed? The mission of the Joris Messens lab is to find answers to these questions. By using a combination of biophysical, biochemical, and structural techniques, we identify redox-sensitive proteins and determine the architecture and conformational flexibility of redox-relay signaling complexes. To understand the crosstalk between redox and metabolite signaling, we develop new tools for sensing subcellular redox and metabolic fluxes.

Your role in the lab

Your expertise will be needed to determine the structural aspects that dictate selectivity of H2O2-driven peroxiredoxin-interactor complexes by cryo-EM. You will also be expected to guide a PhD student working on this topic.

Your profile

Applicants should be team-workers who have obtained a PhD within the field of structural protein biochemistry and should have thorough hands-on expertise with protein expression and purification, in vitro protein complex reconstitution, and with cryo-EM image acquisition and processing methods. Fluency in English and good communication skills are a must. Experience with biophysical techniques or X-ray diffraction crystallography is a plus. 

How to apply?

Please include a cover letter discussing your interests in our laboratory and projects as well as your CV and a list of 3 individuals as references when applying to Jobsoid.