Bioinformatics Single-Molecule Sequencing Scientist

Leuven VIB-KU Leuven Center for Cancer Biology

29 Sep 2017

Leuven

VIB-KU Leuven Center for Cancer Biology

Diether Lambrechts Lab

Bio IT

1

Description

Nanopore sequencing has only been available to researchers for a little over 3 years. Recently, the milestone of sequencing and assembling a human genome on a nanopore sequencing platform was achieved for the first time, indicating that human genome sequencing at scale is now possible with this platform. Through an early-access program, our laboratory has now access to the newest nanopore sequencing device. We are now looking for a talented researcher with computational skills to analyze and interpret the data we are generating. Especially, we are interested in further developing the READ until protocol, which enables the selective rejection of an individual read before it’s being sequenced completely.

You will be working in The Laboratory for Translational Genetics (https://www.vibcancer.be/diether-lambrechts). This research group of Diether Lambrechts is interested in discovering genetic and epigenetic mechanisms that underlie cancer development or contribute to therapeutic resistance of human cancers. We aim for a fundamental understanding of malignant processed, as well as a therapeutic impact. To achieve these goals, we are relying on experimental models of human cancer, cancer patient samples and advanced high-throughput sequencing techniques. Our research which is strongly driven by next-generation sequencing technologies is funded by the ERC, the VIB and other local charities and funding agencies.

In your role, you will support and contribute to projects and collaborations by performing downstream analysis of next-generation sequencing data, particularly those dealing with nanopore sequencing data. Hereto you will apply and optimize standard protocols. Depending on your experience and qualifications you will develop new pipelines for our single-molecule long-reads sequencer. Ideally, you will be(come) responsible for this state-of-the-art long-read sequencing technology. You need to be able to organise and troubleshoot your practical work independently, document it thoroughly and communicate results and experiences with the team in a collaborative and professional manner.

Profile

As an ideal applicant for this position:

  • You have a master degree and/or PhD in the Life Sciences, Engineering, Bioinformatics, Statistics, Computational Science or equivalent.
  • You have experience with or a strong interest in bioinformatics programming and statistics for bioinformatics, including linux, scripting (e.g. Bash) and R (incl. Bioconductor). You also have experience with or a strong interest in high performance computing clusters.
  • You have experience with or a strong interest in the analysis of next-generation sequence data such as whole exome sequencing, whole-genome sequencing, SNP/indel calling, CNV, Structural variation and RNA- Seq.
  • You have experience with or a strong interest in single-molecule, real-time sequencing.
  • Interest and basic knowledge in (cancer) biology or genetics is considered as a plus.
  • You must have good, open communication skills and be willing to support the other scientists of our team
  • If you are applying as a postdoc we require a strong publication track and experience in the majority of the fields mentioned above. 

We offer

  • The ability to learn, work with and become an expert in long-read sequencing technologies.
  • An exciting work environment where quality, professionalism and human contacts are paramount.
  • The ability to work on scientifically exceptional and high impact, state-of-the-art projects.
  • The opportunity to be part of a new, young and dynamic team and provide a meaningful contribution to genetic and oncological research.
  • The planned project duration is estimated at 3 years.

Applicants are invited to send their CV (including a list of your scientific publications) and a cover letter describing your motivation and background.

For more information on this position, please contact Bram.Boeckx@kuleuven.vib.be or Roseline.vandecasteele@kuleuven.vib.be