Postdoc Position on Single Molecule Analysis of Key-Players in Alzheimer’s Disease Pathogenesis

Leuven VIB-KU Leuven Center for Brain & Disease Research

15 Nov 2018

Leuven

VIB-KU Leuven Center for Brain & Disease Research

Wim Annaert Lab

Post-doctoral

1

Description

The VIB Center for Brain and Disease Research (KU Leuven, Belgium), headed by Prof. Patrik Verstreken, is a vibrant and international research centre where key issues relevant for major human neurodegenerative diseases are tackled.

The laboratory for Membrane Trafficking (Prof. Wim Annaert) studies the cellular biology of Alzheimer’s disease (AD) and aims to understand how intracellular transport regulation contributes to intramembrane proteolysis of APP and the production of neurotoxic Aβ peptides.

Recent work from the lab (Sannerud et al., Cell, 2016) showed that PSEN2/γ-secretase generates the prominent pool of intracellular Aβ and familial AD-associated mutations strongly increase the accumulation of longer Aβ. Herein it was striking to find PSEN2 complexes organized in nanodomains on the limiting endosomal/lysosomal membrane.  

This project will focus on exploring this nanodomain organization of PSEN/γ-secretase complexes in cell models including differentiating neurons using subdiffraction microscopy or nanoscopy. The laboratory has in-house PALM/STORM and SIM microscopy and closely collaborates with spectroscopists Prof. Johan Hofkens and Prof. Hideaki Mizuno in the Science and Technology group at KU Leuven to improve nanoscopy modalities and explore novel fluorescent probes. The project is focused on nanodomain analysis and bridges with basic neuro- and lysosomal biology in the context of Alzheimer’s disease pathogenesis.  

Profile

  • We seek a young and ambitious postdoctoral fellow with a molecular, cell biological or biophysical background and proficient experience in confocal microscopy.
  • The ability to work in a multidisciplinary research team as well as effective communication and writing skills and a good mastery of the English language are essential for a successful selection.
  • Expertise in superresolution microscopy (PALM, STORM, SIM) and analysis is of significant added value.

We offer

Financial support is available for 3 years but the successful candidate is encouraged to obtain an independent fellowship (Marie-Curie, EMBO, or National funding organizations) during this time.

How to apply?

Please use the VIB HR Application tool.  Additional required information:

  • Please enclose a motivation letter to your application
  • Please mention the contact details of two references (of which one of your PhD mentor) in the application form

Profile and selected papers of the Annaert lab can be found on: http://www.vib.be/en/research/...

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