The Laboratory of Glia Biology (Holt lab) is part of the VIB-KU Leuven Center for Brain and Disease Research. Astrocytes are a major cell type in the mammalian brain responsible for blood brain barrier formation and maintenance, synapse formation and the modulation of synaptic transmission. The lab has a strong interest in the molecular programs driving these diverse functions. In particular, the lab wants to establish the degree to which functionally specialised astrocytes support neuronal function, and how this may influence neurodegenerative disease.
This project aims to investigate the molecular programs driving astrocyte development and how these gene networks influence functional heterogeneity in adulthood. The project will make extensive use of single cell transcriptome sequencing methods (Incl. spatial mapping technologies).
• Reactive Astrocytes: Production, Function, and Therapeutic Potential. Liddelow and Barres. Immunity. 2017.
• Functional diversity of astrocytes in neural circuit regulation. Ben Haim and Rowitch, Nat Rev Neurosci. 2017.
• Single-cell sequencing-based technologies will revolutionize whole-organism science. Shapiro, Biezuner and Linnarsson. Nat Rev Genet. 2013.
The lab seeks an energetic and motivated post-doctoral scientist for the project.
• Recent Ph.D. in a relevant subject area (Neuroscience, Bioinformatics etc).
• Ability in bioinformatics and programing skills are a must.
• Fluency in English
• Wet lab experience is a bonus but is not essential, as all essential techniques can be taught.
• A creative environment with a diversity of top quality neuroscience research and access to first class core facilities (including single cell sequencing).
• An initial contract for one year which can be extended subject to satisfactory performance.
• Starting data: As soon as possible.
How to apply?
Please use the VIB HR Application tool
Additional required information:
- Please enclose a motivation letter to your application
- Please mention the contact details of two references in the application form.
For more information please contact Matthew Holt.