Postdoc position: plasticity-induced changes in synaptic protein composition in neural circuits

Leuven VIB-KU Leuven Center for Brain & Disease Research

26 Feb 2019


VIB-KU Leuven Center for Brain & Disease Research

Joris de Wit Lab



About the lab

The De Wit lab (Laboratory of Synapse Biology) at the VIB-KU Leuven Center for Brain & Disease Research, Belgium, is seeking a highly motivated postdoctoral fellow to study how experience alters synaptic protein composition in hippocampal circuits. 

Job description

The main goal of our laboratory is to unravel the molecular mechanisms that control synaptic connectivity in developing circuits (see references below). This project aims to use innovative proteomics approaches to investigate how sensory experience alters the protein composition of specific synapses in the hippocampus. You will make use of cell type-specific Cre lines; CRISPR/Cas9-mediated tagging of endogenous proteins; and quantitative proteomics. The role of identified candidate genes will be tested in vivo, using mouse genetics and viral vector approaches combined with (ultra)structural and functional analysis of synaptic connectivity.

Selected references

  • Ribeiro et al. BioRxiv (2019).
  • Rice et al. Science (2019). 363(6423)
  • Condomitti et al. Neuron (2018). 100:201-215
  • Schroeder et al. Neuron (2018). 99:329-344
  • Savas et al. Neuron (2015). 87:764-780



We are seeking a highly motivated, enthusiastic, critical and creative individual to join our team. The candidate should have a strong interest in synapse biology and developmental neurobiology.

  • PhD in neurobiology (molecular, cellular, developmental, systems) or related disciplines
  • A solid publication record with first-author research publication(s) in peer-reviewed international journals
  • Team player

 Desirable but not required

  • Prior experience with quantitative proteomics and bioinformatics is a plus
  • Prior experience with mouse neurobiology and molecular biology is a plus

 We offer

  •  A versatile and challenging job in a vibrant, world-class research environment operating at an international level
  • State of the art research facilities
  • A dedicated training program to broaden your expertise and enhance your skill set
  • A competitive compensation package based on expertise and experience
  • Financial support for at least 2 years. The successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or national funding organizations)
  • Starting Date: as soon as possible

How to apply?

For more information contact Joris de Wit. Please complete the online application procedure and include a detailed CV incl. list of publications, a motivation letter, and the contact information of three referees.