Postdoc position to study mechanisms of neurodegeneration in ALS and FTD

Leuven VIB-KU Leuven Center for Brain & Disease Research

20 Aug 2019


VIB-KU Leuven Center for Brain & Disease Research

Sandrine Da Cruz Lab



About the lab

The VIB-KU Leuven Center for Brain & Disease Research is part of the VIB Life Sciences Institute and is embedded within the University of Leuven, which ranks among the world’s top 50 universities. At our Center, researchers study the cellular mechanisms of health and disease in the central nervous system.

Dr. Sandrine Da Cruz, an established researcher in the field of Amyotrophic Lateral Sclerosis (ALS), is starting up a new lab as of the 1st October 2019 within the VIB-KU Leuven Center for Brain & Disease Research. This new research group will focus on investigating disease mechanisms and novel therapeutic approaches for devastating neurological disorders including ALS and frontotemporal dementia (FTD), the second most common dementia after Alzheimer’s disease.

Job description

We are seeking highly motivated, creative and collaborative applicants with strong background and interest in neurodegeneration and deep experience in cell culture and molecular biology techniques to advance our studies on the molecular mechanisms underlying muscle denervation and axonal degeneration. Elucidating these mechanisms is critical to our understanding of the disorder and key to the development of novel therapeutic approaches.

To unravel the yet poorly understood mechanisms underlying neurodegeneration, the laboratory uses a combination of sophisticated mouse models (previously established in Da Cruz lab), cutting-edge stem cell and genome editing approaches to model in vitro human neurological disorders including ALS and FTD.

Selected References:

Gasset-Rosa et al. Neuron, 2019, 102:339-357
Melamed et al., Nature Neuroscience, 2019, 22:180-190
Lopez-Erauskin et al. Neuron, 2018, 100:816-830
Ditsworth et al., Acta Neuropathologica, 2017, 133:907-922
Da Cruz and Cleveland, Science, 2016, 351:125-6



  • PhD in Neurobiology (molecular, cellular), Life Sciences or related disciplines
  • A solid publication record with first-author research publication(s) in peer-reviewed international journals
  • Team player
  • Strong ability to work in a multidisciplinary research team 

Desirable but not required

  • Prior experience with mouse models is a plus.

We offer

  • A versatile and challenging job with very diverse contacts in a world-class research environment operating at an international level, and various opportunities to broaden your expertise
  • State of the art research facilities
  • A competitive compensation package based on expertise and experience
  • Financial support is available for at least 2 years. However, the successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or National funding organizations).
  • Starting Date: November 2019

How to apply?

Please use the VIB HR Application tool

Additional required information:

  • detailed CV
  • motivation letter describing your research interests and previous research experience
  • names and contact information of 3 references

For more information: please contact Sandrine Da Cruz via email

Info about lab and the center: