Postdoc to investigate the cellular phase of Alzheimer’s disease using spatial transcriptomics

Leuven VIB-KU Leuven Center for Brain & Disease Research

29 Jul 2020

Leuven

VIB-KU Leuven Center for Brain & Disease Research

Bart De Strooper Lab

Post-doctoral

1

Description

The Laboratory for the Research of Neurodegenerative Diseases headed by prof. Bart De Strooper is a vibrant environment where key issues related to Alzheimer’s disease are tackled. We are currently looking for a highly skilled and motivated postdoc to join our multidisciplinary project on the cellular response to Alzheimer’s pathology (De Strooper and Karran, Cell, 2016). 

In this project we will investigate why some people remain protected against Alzheimer’s Disease despite the presence of amyloid plaques. Understanding why some people are resilient to Alzheimer’s disease will help us to identify new drug targets. The candidate will use spatial omics such as spatial transcriptomics, in situ sequencing, and multiplexed proteomics to untangle the cellular response to amyloid plaques and tangles in resilient and Alzheimer’s brains.

Profile

Required

  • PhD in biomedicine, genetics or equivalent
  • Strong background and hands-on experience with brain pathology
  • Interested to work in the field of Alzheimer’s Disease
  • Critical mindset, fast learner & team player
  • Ability to collaboratively lead a multidisciplinary project with international and national partners in academia, industry and the clinics
  • Project management and effective communication skills
  • Good mastery of English language

Appreciated

  • Experience in image analysis
  • Familiarity with R or python
  • Solid scientific and operational knowledge of fit-for-purpose state-of-the-art omics platforms (transcriptomic, genetics, proteomics,…) at single cell resolution and the selection and application of appropriate data analysis methodologies, especially in the context of human translational studies
  • Knowledge on the genetics of Alzheimer’s disease

We offer

  • A stimulating, diverse, international and exceptionally strong research environment in a world-class academic laboratory with a focus on Alzheimer’s disease
  • Opportunity to learn state of the art technology
  • Opportunity to work with an excellent bioinformatics team
  • Access to state-of-the-art infrastructure,
  • Financial support is available for at least 2 year. However, the successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or National funding organizations).

Start date: as soon as possible - the position is available immediately

How to apply?

Please complete the online application procedure and include a detailed CV, a motivation letter describing research interests and previous research experience and a list of publications.

For more information: please contact weiting.chen@kuleuven.vib.be.