Postdoctoral position

Brussels VIB-VUB Center for Structural Biology

13 Jan 2023


VIB-VUB Center for Structural Biology

Wim Versées



At the VIB-VUB Center for Structural Biology (Vrije Universiteit Brussel / VIB), we are looking for a highly qualified and motivated postdoctoral researcher with a strong background in Cryo-EM and/or X-ray crystallography, biochemistry and biophysics, and interested in biochemical and structural studies on bacterial persistence pathways.

Project description:

Due to the development of resistance to antibiotics, bacterial infections are becoming more life-threatening every year. In addition to resistance, bacterial persistence offers an important means to avoid clearance of infections. Persisters are formed by phenotypic switching to an antibiotic-tolerant state, rendering a small subset of cells within an isogenic population capable of surviving antibiotic treatment. Within this ongoing research project we want to gain more insight into the mechanisms of persistence by unravelling the associated molecular pathways down to atomic resolution (e.g. Verstraeten et al. Mol. Cell 2015; Gkekas et al. J. Biol. Chem. 2017; Verstraeten et al. Mol. Microbiol. 2019). The project is part of an interdisciplinary Excellence of Science program in collaboration with the teams of Jan Michiels, Régis Hallez, Françoise Van Bambeke, Steven Ballet and Jörg Vogel. Within this consortium you will use single particle cryo-EM and X-ray crystallography, in combination with biophysical methods and enzyme kinetics, to gain insight in the role of important persistence proteins and their interactions. This information will subsequently be used to intervene with these proteins and processes to devise new potential therapeutic strategies.

For more information about the Versées lab see

Required skills and experience:

  • PhD in Biochemistry, Molecular Biology, Bio-engineering or equivalent
  • Strong background in protein expression, purification and characterization
  • Experience in Cryo-EM and/or X-ray crystallography is mandatory
  • Proficient in written and spoken English
  • Strong organizational and interpersonal skills


Please send applications (including CV, research experience, and at least two names and contact information for references) to:

Wim Versées, VIB-VUB Center for Structural Biology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel -

About CSB: 

The VIB-VUB Center for Structural Biology focusses on the structure and dynamics of macromolecular complexes in health and disease. Our multidisciplinary team of about 100 researchers is housed in new laboratory facilities and combines extensive expertise in structural biology (state of the art in-house cryo-EM, X-ray crystallography, NMR, SAXS, and atomic force microscopy), biophysics, enzymology and molecular biology.

VIB values diversity - in backgrounds and in experiences. The institute needs people from all backgrounds and ways of life to help build a thriving scientific environment. VIB is therefore looking for candidates who are not only strong in their own aptitudes but care deeply about supporting each other's growth. VIB's collaborators are people with different strengths, experiences and backgrounds, who share a passion for science that generates impact in science and in society. Diversity not only includes race and gender identity, but also nationality, age, disability status, sexual orientation, religion and many other parts of one’s identity. All of VIB’s employees’ points of view are key to its success, and inclusion is everyone's responsibility.