The Molecular Biology of Leukemia laboratory (Prof. Jan Cools, VIB, KU Leuven) is looking for a motivated postdoctoral researcher for studies of oncogenic pathways in leukemia mouse models.
The project will focus on (i) leukemia mouse models by use of transgenic animals as well as bone marrow transplant assays; (ii) the study of transcription factor binding to DNA by ChIP-seq; (iii) the effect on transcription by other mutations.
This position is open to both junior and experienced scientists. We look for highly motivated candidates with an interest in leukemia research and with a track record in cell biology, mouse models and/or transcription factor function. We provide a stimulating and strong scientific environment in a cancer department.
Further info on
- De Keersmaecker K, et al. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nature Genetics. 2013; 45(2):186-90.
- Dagklis A, et al. Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors. Blood. 2016; 128(23):2642-2654.
- Vicente C, et al. Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia. Haematologica. 2015; 100(10):1301-10.
- PhD in biology, biochemistry, biotechnology or equivalent
- Broad expertise in basic research technology (Western blotting, gene expression, cell culture, flow cytometry, etc.)
- Good publication record and strong communication skills
- Experience with transcription factors, ChIP-seq, RNA-seq, etc. is a plus
- Experience with xenograft mouse models is a plus
VIB-KULeuven is an exciting, interdisciplinary research institute with excellent facilities and strong research groups in genetics, oncology, neurobiology, immunology, virology, molecular biology and translational research. The laboratory of Prof. Jan Cools is located on the Gasthuisberg campus of the KU Leuven (Faculty of Medicine, Center for Human Genetics) and has on-site mouse facilities, sequence facilities and access to leukemia samples.