The laboratory of Professor Peter Carmeliet (part of the Center for Cancer Biology, CCB) is one of the research departments of VIB (Vlaams Instituut Biotechnologie) located at the KU Leuven – Campus Gasthuisberg. The lab is focusing on the development of blood vessels (angiogenesis) and vascular metabolism, and consists of 20 plus junior researchers. The lab is seeking a dynamic, highly motivated and experienced Staff Scientist to contribute to the state-of-the-art analysis of cellular metabolic pathways by applying and developing metabolic tracer studies (using stable isotope-labeled tracers) combined with gas and liquid based mass spectrometry(GC-/LC-MS). The focus of the lab is to characterize the role of metabolism during the process of angiogenesis in health and disease in order to identify novel therapeutic applications. Under the supervision of Prof. Carmeliet, a team is currently set-up to analyze omics-data with bioinformatics tools and to provide a link between mass spectrometry related data analyses (metabolomics, proteomics), next-generation sequencing (RNA-sequencing, genomics including single-cell analyses) and endothelial cell biology.
To complement this team, we are seeking a (senior) biochemist (postdoc level with relevant years of experience) with a focus on development and implementation of metabolic phenotyping/metabolomics to address specific research questions and data acquisition applying advanced mass spectrometry platforms. The candidate will collaborate extensively with leading-edge researchers and bioinformaticians and will support researchers to understand better the metabolic changes occurring during angiogenesis in health and disease.
You are responsible for:
- Working independently to analyze mass spectrometry (GC-/LC-MS) data and to complement a team of bioinformaticians, under supervision of Prof. Carmeliet
- Adapting and developing MS technologies for the identification and quantification of metabolites from biological tissues, cells and fluids and tailoring these towards specific research questions
- Assisting group leaders and scientists in data analysis and interpretation of the data
- Organizing weekly team meetings to update your research results
- You have strong data analytical skills and a fundamental knowledge/background in mass spectrometry (GC-MS and/or LC-MS) for metabolite determination and identification
- Experience in advanced metabolomics technologies and isotopic labeling for metabolic tracing is preferred
- Candidates are interested in analyzing and integrating complex omics- and clinical datasets, and in working in a multidisciplinary environment of experts in biomedical sciences, metabolomics, transcriptomics and bioinformatics
- Candidates have a PhD in (analytical) chemistry, biochemistry, biology or related field
- You are interested and motivated to work on ambitious projects in an open, dynamic, competitive and driven team
- You should have excellent organizational and supervisory skills, you can inspire and motivate a team
- You should have a strong ability to handle multi-tasks spontaneously, troubleshoot on MS-related issues, meet timelines as well as work independently and accurate
- Good communication skills in spoken and written English
- You have a good publication record (including at least one paper as a first author) in peer-reviewed international journals, with an emphasis on quality rather than quantity of publications.
- Access to state-of-the-art MS-technologies in biomedical research
- The opportunity to work in a multidisciplinary international team
- and contribute to the biological validation by using omics data sets
- A dynamic working environment in which quality, professionalism and team spirit are encouraged
- A competitive remuneration package, a stimulating scientific
- surrounding in a young, enthusiastic, motivated team (with English as
- main language)
- Long-term career opportunities
- Excellent training conditions
- starting as soon as possible.