Postdoc Position in functional analyses of gamma-secretase proteases in Alzheimer’s brains

Leuven VIB-KU Leuven Center for Brain & Disease Research

17 Jan 2019

Leuven

VIB-KU Leuven Center for Brain & Disease Research

Lucia Chavez Gutierrez Lab

Post-doctoral

1

About the lab

The Laboratory for Proteolytic Mechanisms in Neurodegeneration headed by Prof. Lucia Chavez Gutierrez at the VIB-KU Leuven Center for Brain & Disease Research is looking for a postdoctoral researcher to investigate gamma-secretase-mediated intramembrane proteolysis in the human brain and its link to Alzheimer's disease pathogenesis.

The main aim of the project is to characterize the function of gamma-secretase intramembrane proteases in the human brain and identify novel endogenous modulators of their activity, all in connection with Alzheimer's disease.

Job description

You will be working on the development of ad-hoc methods for the determination of the mechanisms of action of intramembrane proteases. You will perform protein expression and purification for biochemical assays, structure-function analysis, proteomics and lipidomics.

Profile

Essential

  • Applicants should have obtained a PhD in the last 4 years within the field of protein biochemistry, bio-engineering, molecular biology or equivalent
  • Highly motivated and creative
  • Good communication skills in English
  • Expertise in protein sciences
  • Ability to work independently while embedded in a team.

Desirable but not required

Expertise in:

  • Membrane proteins
  • Reconstitution of membrane proteins in lipid environments
  •  Molecular Biology of the synapse
  • Neuroscience

We offer

  • Competitive salary and benefits
  • Access to state-of-the art infrastructure and tools
  • A highly interactive, stimulating and international environment of VIB.
  • Financial support is available for 2 years. However, the successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, EMBO, or National funding organizations).

How to apply?

Please use the VIB HR Application tool

Additional required information:

  • CV
  • Please enclose a cover letter presenting your interests in the project
  • Please mention the contact details of two references in the application form.

For more information, please contact lucia.chavezgutierrez@kuleuven.vib.be or follow the links below: